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This is why many of the known GLP-1 medication side effects are linked to digestion, including constipation
doi: 10.3389/FENDO.2025.1545593 149
If we recall that approximately 25% of total weight loss in persons with obesity is accounted for by FFM, the authors found that fat free mass accounted for 33%, 39%, and 25% of total weight loss for retatrutide ( Phase 2 data only, not yet FDA approved), semaglutide and tirzepatide respectively whereas fat mass loss accounted for 67%, 61%, and 75% respectively
Majd, M., Saunders, E
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