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Body Composition Results (12mg Dose, 48 Weeks) Context on lean mass loss: Some lean mass loss (25-30%) is typical with any significant weight loss, including bariatric surgery Lean mass includes muscle, water, bone, and organs, not just muscle The glucagon component may help preserve muscle compared to GLP-1-only drugs Resistance training + adequate protein (1.0-1.2g/kg daily) can minimize muscle loss Visceral Fat Reduction Retatrutide also led to large reductions in visceral adipose tissue (VAT), the fat surrounding internal organs that's linked to metabolic disease
Phase 2 clinical trials are currently ongoing assessing additional GLP-1 agonists, lixisenatide (NCT03439943), liraglutide (NCT02953665), and semaglutide (NCT03659682) for the treatment of PD [97]
Retatrutide is unique among current weight loss medications in targeting the glucagon receptor, which promotes thermogenesis and fat oxidation
During this titration period, stick to your schedule as precisely as possible
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