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Destruction of oxidatively-damaged RBCs is accomplished extravascularly by macrophages in the reticuloendothelial system 56
In cancer therapy, P-gp plays a crucial role in multidrug resistance (MDR) by actively pumping out chemotherapeutic agents, thereby reducing their intracellular concentration and leading to treatment failure (Fig
10.1111/pce.12227 166 SpissoA
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