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The most recent Global Burden of Diseases, Injuries, and Risk Factors (GBD) study reported an age-standardized prevalence rate of 448.6 per 100,000 people in 2021 compared to the 2019 editions cited rate of 599 cases per 100,000 people [2,3,4]

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Cancer cells metabolically fertilize the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors