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The Wegovy label reports that kidney injury "occurred more frequently during dose titration" (the step-up period) and advises monitoring kidney function "especially during dosage initiation and escalation." That lines up with how the side effects behave
3.1 Tirzepatide effects: glucose lowering effects of tirzepatide Tirzepatide, a once-weekly subcutaneous injection, was FDA approved in May 2022 as an adjunct treatment with diet and exercise to improve glycemic control in adults with Type 2 diabetes [43]
The molecule also modulates nitric oxide signaling, dampens local inflammation, supports tendon and ligament repair, and protects gastric mucosa from NSAID injury, which is incidentally why I sometimes pair it with the analgesia plan
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