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Others may require medical evaluation

They are generally not recommended for patients with a personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), those who are pregnant or breastfeeding or planning pregnancy, patients with a known allergy to the medication, severe gastroparesis or serious digestive motility disorders, active pancreatitis or significant pancreatitis history, serious gallbladder disease, certain kidney conditions, or active eating disorder concerns

But it can lead to uncomfortable constipation that requires active management

With semaglutide coming in at 5 points and placebo at 26.7, this represents a major estimated treatment difference of -14.9%