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There is also the question of what happens when GLP-1 therapy is eventually stopped: weight tends to return, suggesting that the underlying biology of obesity has not been fundamentally altered
Mechanistically, TMAO may promote autophagy-dependent cell death in human renal proximal tubular epithelial cells by activating the PERK/ROS pathway, thereby aggravating calcium oxalate crystal deposition and kidney injury
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These medications can significantly reduce hunger and caloric intake, leading to substantial weight loss
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