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Thus, although E 2 causes genetic changes conducive to its own inactivation, the decrease in estrogenic activity yields a toxicologically active metabolite that constitutes an additional pathway of estradiol-dependent carcinogenesis

And for patients with a lower body mass index, or BMI, microdosing can be a better option because they might not need as high of a dose

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[32] In SURMOUNT-1, tirzepatide produced mean weight loss of 15.0%, 19.5%, and 20.9% at doses of 5 mg, 10 mg, and 15 mg, respectively, compared with 3.1% with placebo at 72 weeks