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This function is critical for maintaining precise neurotransmission, as it helps regulate extracellular glutamate concentrations to prevent excitotoxic damage

Based on the strength of the clinical data, we expect Wegovy to be added to formularies with utilization management restrictions for prior authorization to prevent off-label use, shorter initial approval periods (e.g., six months approved initially) to ensure efficacy, and quantity limits to reduce stockpiling and waste

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The TCN2-cobalamin-TCBLR complex is internalized via endocytosis