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Phase 3, Remodeling (Weeks 3-8): Both peptides contribute to extracellular matrix reorganization, reducing scar formation and improving the mechanical quality of repaired tissue

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Then, the rate-limiting enzyme in arginine synthesis, argininosuccinate synthetase 1 (ASS1), catalyzes the conversion of citrulline and aspartate into argininosuccinate, which is then cleaved into arginine and fumarate by argininosuccinate lyase (ASL) (Figure 1)