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In line with these findings, a study group found phosphorylated SN deposits in proximal peripheral nerves of PD patients with small nerve fiber PN compared to atypical parkinsonism and healthy controls, with no significant differences between LDopa exposure or Vit B12 deficiency (Donadio et al
As miR-146a climbs, two central TLR signaling proteins named IRAK1 and TRAF6 may fall and consequently may fail to relay inflammatory signals through the cell, including routes tied to NF-B activation that would otherwise weigh heavily on inflammatory output
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