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The most commonly reported side effects are mild and transient, including injection site reactions (redness, slight swelling, or tenderness), mild headaches during the initial days of use, and occasional dizziness or lightheadedness, particularly when starting the peptide

Later work examined NNMT inhibition combined with dietary changes in obese mice, reporting reductions in body weight, fat mass, and hepatic fat, alongside shifts in gut bacterial populations

in total, 9 genera (including the unclassified group) and 38 metabolites met these criteria (metabolites published in Sampson et al., 2021 13 )