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In individuals with obesity, excess fat can lead to: Altered sex hormone levels : Increased aromatisation of androgens to oestrogens in adipose tissue, potentially affecting testosterone levels in both men and women [14] Insulin resistance : Which may impair endothelial function and reduce blood flow necessary for sexual arousal Elevated inflammatory markers : Chronic low-grade inflammation associated with obesity can negatively impact vascular and sexual health As weight decreases, these parameters often improve

First, the poly-agonist thesis has achieved sufficient validation that the competitive question is no longer whether multi-receptor approaches will succeed, but rather which specific receptor combinations and ratios will prove optimal for different patient populations