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Except for controlled-release medication, disintegration of a solid drug product usually occurs more rapidly than drug dissolution and permeation

Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells

Daily (or multiple daily) injections are required

In addition, these workers found that antidepressant treatment may lead to defective spindle assembly and altered organelle distribution, with changes in the protein concentrations of small C-terminal domain phosphatases-1 and -3, nuclear mitotic apparatus (NuMa), and calnexin occurring during cell division in vitro