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[18] The Endocrine Society's position statement on GH secretagogues notes: "Ghrelin receptor agonists, including ipamorelin, represent a pharmacologically rational approach to physiologic GH stimulation, but their use outside approved indications requires careful patient selection and monitoring given the absence of large-scale safety data." [1] The American Association of Clinical Endocrinology (AACE) has similarly called for outcome-based surveillance registries for patients receiving compounded peptide therapies, recognizing that real-world safety data collection is the primary tool available in the absence of phase III trials

References: Acheampong AA, et al (1995): Comparative ocular pharmacokinetics of brimonidine after a single dose application to the eyes of albino and pigmented rabbits

In AHH-1 lymphocytes at low doses (4.8 gy or less), gene expression and protein levels of both pro- and anti-ferroptotic biomarkers decreased

The drugs can cost about $1,000 a month and are usually covered for other conditions like diabetes