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In the SURPASS and SURMOUNT trials, Lilly has so far compared tirzepatide to older treatments or placebo (for T2D and obesity)

GLP-1 drugs are effective at reducing cytokine-driven inflammation because they activate AMPK, which, in turn, inhibits NF-kB activity, thereby decreasing cytokine production (9)

When a patient has progressed to insulin therapy, that status signals disease severity, affects risk stratification, and carries reimbursement implications under Medicare Advantage HCC models