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Image credit: KaterynaBorodina/Shutterstock.com Obesity treatment has been revolutionized by the introduction of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) like semaglutide, and dual GLP-1 RA/glucose-dependent insulinotropic polypeptide [GIP] receptor agonists like tirzepatide

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Since the net charge of CAND is -0.2, resulting in an overall neutral charge, it is difficult for CAND to be effectively transported to the cell nucleus on its own