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Sequencing data were first surveyed for SNVs and small insertion/deletions (indels) using an ensemble variant calling pipeline designed to take advantage of the multiple samples per patient (see Methods)
The dose escalation period is important for tirzepatide because it allows the doctor to determine the optimal dosage for each individual patient
The GLP-1 group had notably lower rates of death and major cardiac events
A clinician can also help adjust the dose if you feel unwell on semaglutide or tirzepatide
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