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Many diets and exercise programs inadvertently lead to muscle loss, which can slow the metabolism and make weight maintenance more difficult
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Disclosures The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article
HIFs are intracellular transcription factors, long considered undruggable due to the absence of well-defined enzymatic pockets and the need to disrupt protein-protein or protein-DNA interactions (218, 219)
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