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[27] [28] However, a large-scale clinical study published in 2012 did find a modest benefit from chelation therapy in improving outcomes for patients with a prior heart attack
This effect is irrespective of whether or not you have diabetes, as AMPK is involved in all of our tissues, and metformin offers broad-spectrum support against conditions like obesity, cancer, heart disease, and even neurodegenerative conditions
Very large doses can result in lactic acidosis (a drop in pH of the blood) and coma (Ferner 2011
Kaiya et al., 2003
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