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The compound modulates neuronal activity in the lateral hypothalamus, specifically silencing GABAergic neurons that promote feeding behavior, thereby reducing the drive to consume food while enhancing satiety responses
[6] Lactobacillus rhamnosus: TMAO Reduction in Human Trials A systematic review published in Nutrients in 2022 evaluated all controlled probiotic intervention studies through early 2022 measuring plasma TMAO levels
A notable study examined how fragment 176-191 affected weight loss and fat burning in mice with the ADRB3 knockout gene
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