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2022;323:E21E32
The virus rapidly generates intracellular free radicals and actively inhibits the DNA damage repair proteins necessary for the body to synthesize its own glutathione
For instance, a two-stage master regulator analysis, Virtual Inference of Protein-activity by Enriched Regulon (VIPER), was conducted on TLR2- and TLR4-responsive gene signatures in macrophages
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