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We hypothesize that the role of HPV-16 E7 is to establish a subset of GSTP1 molecules that is inaccessible to oxidative attack, thus creating a reservoir of reduced monomeric GSTP1

However, these findings were not statistically significant ( p =0.546)

Degradation of glutathione S-conjugates in Physcomitrella patens is initiated by [PMID: 21616930] Laboratory literature summary: Degradation of glutathione S-conjugates in Physcomitrella patens is initiated by cleavage of glycine

These metabolic and proteomic changes collectively indicate that in ATP6AP1 KO cells show a metabolic phenotype protected from ACT-induced rerouting of carbons, suggestive that partial v-ATPase disruption appears to reduce cellular reliance on mitochondrial oxidation, enabling resistance to mitochondrial insults while limiting biosynthetic capacity