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Higher pH (more alkaline) in the lungs causes carbon dioxide to be released and stimulates the binding of oxygen Levels of other molecules (hydrogen ions, carbon dioxide, 2,3-bisphosphoglyceric acid, IHP, chloride, and phosphate) In people acclimated to high altitudes, the concentration of 2,3-BPG in the blood increases, which allows a larger amount of oxygen to be delivered to the tissues Temperature Increases in temperature decrease oxygen saturation of hemoglobin Note that inside the body, the pH and temperature are generally within a very narrow range, from 7.35 7.45 and 97.0 99.8 degrees Fahrenheit (36.1 37.7 degrees Celsius), respectively [6]

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doi: 10.1038/srep37336 12 SpohnSMaweG

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