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Vitamin B12 is water-soluble but stored in the liver, allowing high serum levels to persist after large supplemental doses
The practical concern is additive nausea and additive appetite loss during the GLP-1 titration phase, and the real risk of losing lean mass if intake drops too far
When preparing a working solution, use an appropriate sterile reconstitution solution or compatible laboratory solvent or buffer in accordance with validated laboratory procedures
Improper storage could lead to vitamin degradation (losing potency) or increased risk of injection site reactions (if contaminants or precipitates form), so patients and providers should take the storage guidelines seriously
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