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In diet-induced obese mice, chronic Retatrutide dosing produced greater reductions in adipose mass and food intake than matched-exposure Semaglutide or Tirzepatide comparators, with indirect calorimetry showing increased energy expenditure attributable to the GCGR component and reduced hepatic triglyceride content on histology
Its the first once-weekly GLP-1 receptor agonist to obtain approval for this reason
Key areas of scientific study include: Signal Transduction: Analyzing the intracellular signaling cascades triggered by multi-receptor agonism
and Ahmed, O.G
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