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Doses of 45 to 50Gy in 15 to 25 fractions are sufficient to achieve disease control in the majority of patients
thus, the levels of pyruvate carboxylase can greatly affect the sensitivity of tumor cells to inhibition of glutamine metabolism 111
Crossing the barriers as well as subsequent promoting antioxidant activity appear to be, to some degree, dependent on the chemical form, since the organic form of Se was proven to be more powerful in increasing the expression and activity of TXNRD, GPX1 and GPX4 (Song et al., 2014)
Dato-DXd showed encouraging antitumor activity in phase I TROPION-PanTumor01 dose-escalation and dose-expansion study evaluating Dato-DXd in solid tumors, in which patients were not selected based on TROP2 expression [40,41]
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