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15 Human serum albumin (HSA) and IgG have plasma half-lives of around 21 days, owing to HSA and the Fc domain of IgG interacting with the neonatal Fc receptor expressed in blood vessel endothelial cells, which rescues the proteins in the endosomes after pinocytosis, preventing them from entering the lysosomal pathway for destruction
However, clinicians should remain vigilant for any changes in neurological status, as the metabolic improvements from better diabetes control may occasionally necessitate adjustments to Parkinson's medications
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