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Comparison with the binding modes of other dual and triple agonists highlight that the N-terminal and C-terminal regions of the peptide confer receptor selectivity, whereas the middle region offers opportunities for sequence optimization to refine receptor engagement, thereby presenting a useful template for designing better unimolecular therapeutics
For example, collagen and gelatin can provide glycine-, proline-, and hydroxyproline-rich peptides that support connective tissue, skin, joints, and the gut lining
10.1111/j.1528-1157.1997.tb01263.x 26 MccoinC
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