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Supplementary Section 3)
More serious but less common adverse effects that warrant prompt medical attention include: Acute pancreatitis: Seek urgent medical review if you experience severe, persistent abdominal pain, particularly if it radiates to the back Gallbladder disease: Rapid weight loss associated with GLP-1 class agents may increase the risk of gallstones
These include nausea, vomiting, and diarrhea, which are common to all incretin mimetics
When used as monotherapy or with medications that do not independently cause hypoglycemia, tirzepatide has a low intrinsic risk of causing clinically significant hypoglycemia
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