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As mentioned above, the regulation of processes such as cell survival and cell death is a hallmark of TNF- in both inflammatory diseases 27 and cancers 37

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This reaction, when it occurs, typically reverses within two to four weeks of discontinuation

the so called epithelial melanocytic cells, which show immunoreactive expression of HMB45 and CKAE1/AE3, with a weaker staining pattern for NSE and Vimentin