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522 A mechanistically distinct approach is exemplified by acacetin, an HSP90 ATPase inhibitor that suppresses the folding of cyclooxygenase-2 (COX-2), leading to ubiquitin-mediated COX-2 degradation and a downstream reduction in inflammatory signaling

It is important to note that significant or persistent pain at injection sites is uncommon and may indicate improper technique or, rarely, local adverse reactions requiring clinical evaluation