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This initial recognition step allows the peptides N-terminus to engage deep within the receptor TMD core, triggering a conformational change proximal to the intracellular region that results in G protein coupling and activation of the downstream signalling cascade 3,4,5,6,7
The peptide sequence Gly-His-Lys chelates a single Cu(II) ion through the histidine imidazole nitrogen and the deprotonated amide nitrogens of the backbone
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(2024) Glutathione: A Key Regulator of Extracellular Matrix and Cell Death in Intervertebral Disc Degeneration
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