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Short-acting GLP-1 agonists like exenatide (taken twice daily) may produce more immediate effects on post-meal glucose levels, whilst longer-acting weekly formulations such as semaglutide or dulaglutide provide more sustained action but may take longer to reach steady-state concentrations in the body

Moreover, bone microarchitecture/strength changes assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) are lacking

Particularly for those noticing the effects of the sleeve wearing off typically after 24 years, semaglutide provides another layer of support

Cjc would normally be dosed once or twice a week