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35 Significant advances in pharmacological treatment have primarily focused on HFrEF, the current therapy for which is built on four key pillars: angiotensin receptorneprilysin inhibitor (ARNI) or, alternatively, ACE inhibitors or angiotensin receptor blockers
We implement strict safety netting protocols, providing clear guidance on when to seek urgent medical help, which is especially critical when managing the absorption window of oral medications discussed in previous sections
These simulations utilized the lowest-energy solution of the NMR-derived ensemble of the p53 TAD2 -FOXO4-DRI complexes as our starting geometry (see methods)
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