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2011, Jan, 22;45(1):10109 Alderson NL, Wang Y, Blatnik M, Frizzell N, Walla MD, Lyons TJ, et al
Mitochondrial engagement, including binding to voltage-dependent anion channels, can heighten oxidative stress in nonlesional tissues and contribute to organ dysfunction independent of lesion-directed ferroptosis (94, 95)
B12 deficiency can lead to a range of symptoms, including fatigue, weakness, and anemia, which can significantly impact a persons quality of life
This range derives from scaling the effective doses in rat studies (approximately 10 micrograms per kilogram of body weight) to human physiology using established interspecies conversion factors
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