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Since they are most associated with the Commander format, you can potentially use them in that format if you "rule zero" it, asking your playgroup if it's okay to play with them

$1.49 Whiptongue Hydra Kamigawa: Neon Dynasty Commander Decks $1.79 Vastwood Hydra Commander 2020 $2.79 Hungering Hydra Core Set 2019 $1.79 Gargos, Vicious Watcher (Resale Foil) Promotional $1.79 Mistcutter Hydra Theros $0.99 Hooded Hydra Murders at Karlov Manor Commander Decks $1.49 Vastwood Hydra 2014 Core Set $0.49 Hydra Broodmaster Modern Horizons 3 Commander Decks $0.35 Wren's Run Hydra Modern Horizons 2 $2.49 Managorger Hydra Bloomburrow Commander Decks $0.35 Wildwood Scourge Foundations $1.79 Capricopian Commander 2020 0 results found

In 2024, this card returned as part of Ravnica Remastered, and its easily that sets most expensive card

Blastoise (Holo) - 30,108 Taking second place is the holographic Blastoise with an estimated resale value of 30,108